SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression[S]

Cholesterol and fatty acid biosynthesis are regulated by the sterol regulatory element-binding proteins (SREBPs), encoded by Srebf1 and Srebf2. We generated mice that were either deficient or hypomorphic for SREBP-2. SREBP-2 deficiency generally caused death during embryonic development. Analyses of...

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Detalhes bibliográficos

Principais autores:	Laurent Vergnes, Robert G. Chin, Thomas de Aguiar Vallim, Loren G. Fong, Timothy F. Osborne, Stephen G. Young, Karen Reue
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-03-01
coleção:	Journal of Lipid Research
Assuntos:	sterol regulatory element-binding protein 2 sterol regulatory element-binding protein 1c gene regulation cholesterol synthesis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520354407
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