ALDOC modulates astrocytic glycolysis and AMPK/mTOR/HIF-1α signaling in Alzheimer’s disease

AimsAstrocytes provide crucial metabolic support for neurons and undergo significant metabolic changes in Alzheimer’s disease (AD). Aldolase C (ALDOC), an astrocyte-enriched glycolytic enzyme, may play a role in this process. This study aimed to investigate whether ALDOC modulates astrocytic metabol...

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Detalhes bibliográficos

Principais autores:	Zhenyuan Zhang, Yanmei Bai, Xiangjian Zhang, Jian Zhang, Guofeng Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
Colecção:	Frontiers in Neuroscience
Assuntos:	aldolase C (ALDOC) Alzheimer’s disease (AD) astrocytes glycolysis hypoxia-inducible factor-1α (HIF-1α) metabolic regulation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1847340/full
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