Nucleofection-based screening of chimeric antigen receptor candidates in human natural killer cells

Chimeric antigen receptor (CAR)-modified cell therapy products approved for clinical treatment of hematological malignancies have hitherto been based on T cells. NK cells represent a promising immune cell type that can be considered for CAR engineering due to their potential to be generated as off-t...

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Autors principals:	Chelsia Qiuxia Wang, Leonard Leong, Lei Yang, Shengli Xu, Kong-Peng Lam, Andre Boon-Hwa Choo, Andy Hee-Meng Tan
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	chimeric antigen receptor (CAR) natural killer (NK) cells nucleofection mRNA screening
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557766/full
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