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Inhibition of glutamine metabolism blocks tumor growth and sensitizes ccRCC to immune checkpoint blockade

Abstract Background Metabolic reprogramming of glutamine plays a pivotal role in the progression of clear cell renal cell carcinoma (ccRCC). Although inhibition of glutamine metabolism has been shown to suppress ccRCC progression, its effect on tumor immune evasion remains poorly understood. Methods...

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Principais autores: Guofeng Ma, Huiqing Jia, Xintao Tian, Guipeng Wang, Xiangyan Zhang, Zhiyuan Mi, Yuefeng Jia, Liping Wang, Zhijuan Liang, Dan Li, Xin Mao, Ye Liang, Haitao Niu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Journal of Translational Medicine
Assuntos:
Glutamine antagonist
Glutaminase inhibitor
PD-L1
Immune checkpoint blockade
ccRCC
Acesso em linha:https://doi.org/10.1186/s12967-026-07705-1
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