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WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway

Abstract With no lysine kinase 1 (WNK1) phosphorylates and activates STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress responsive kinase 1 (OSR1) to regulate ion homeostasis in the kidney. Mutations in WNK1 result in dysregulation of the WNK1-SPAK/OSR1 pathway and ca...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Masahiro Shimizu, Hiroshi Shibuya
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2022-09-01
Rangatū:Scientific Reports
Urunga tuihono:https://doi.org/10.1038/s41598-022-20271-y
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