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Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and...

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Detalhes bibliográficos
Principais autores: Michael Saitakis, Stéphanie Dogniaux, Christel Goudot, Nathalie Bufi, Sophie Asnacios, Mathieu Maurin, Clotilde Randriamampita, Atef Asnacios, Claire Hivroz
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-06-01
coleção:eLife
Assuntos:
Acesso em linha:https://elifesciences.org/articles/23190
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