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Extracellular Citrate Fuels Cancer Cell Metabolism and Growth

Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for anabolism and membrane biogenesis, requires citrate. We revie...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Sebastian Haferkamp, Konstantin Drexler, Marianne Federlin, Hans J. Schlitt, Mark Berneburg, Jerzy Adamski, Andreas Gaumann, Edward K. Geissler, Vadivel Ganapathy, E. Kenneth Parkinson, Maria E. Mycielska
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-12-01
Schriftenreihe:Frontiers in Cell and Developmental Biology
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fcell.2020.602476/full
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