Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis. We previously identified a role of de novo nucleotide biosynthesi...

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Bibliografische Detailangaben

Hauptverfasser:	Julia A. Pinette, Jacob W. Myers, Woo Yong Park, Heather G. Bryant, Alex M. Eddie, Genesis A. Wilson, Claudia Montufar, Zayedali Shaikh, Zer Vue, Elizabeth R. Nunn, Ryoichi Bessho, Matthew A. Cottam, Volker H. Haase, Antentor O. Hinton, Jessica B. Spinelli, Jean-Philippe Cartailler, Elma Zaganjor
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-10-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	lipid droplets adipocytes nucleotides purine pyrimidine adipogenesis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227524001469
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