Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model

Abstract Background L-arginine is a critical determinant of central nervous system (CNS) function through nitric oxide (NO) production. Its uptake from plasma into brain is dependent on carrier-mediated transport across the blood-brain barrier (BBB). Transport kinetics of L-arginine BBB uptake have...

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Hauptverfasser:	Olivia C. Milam, Cullen P. Wolford, Geoffrey L. Pecar, Joshua J. Applegate, Maxine E. Casto, Dominic J. Gabriele, Austin S. Nestor, Paul R. Lockman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-06-01
Schriftenreihe:	Fluids and Barriers of the CNS
Schlagworte:	L-arginine Amino acid homeostasis Amino acid brain transport Blood-brain barrier Nitric oxide Transport kinetics
Online-Zugang:	https://doi.org/10.1186/s12987-026-00832-3
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