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A conserved viral amphipathic helix governs the replication site-specific membrane association.

Positive-strand RNA viruses assemble their viral replication complexes (VRCs) on specific host organelle membranes, yet it is unclear how viral replication proteins recognize and what motifs or domains in viral replication proteins determine their destinations. We show here that an amphipathic helix...

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Autors principals: Preethi Sathanantham, Wenhao Zhao, Guijuan He, Austin Murray, Emma Fenech, Arturo Diaz, Maya Schuldiner, Xiaofeng Wang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2022-09-01
Col·lecció:PLoS Pathogens
Accés en línia:https://doi.org/10.1371/journal.ppat.1010752
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