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Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to reduce cardiac BCAA levels and demonstrated positiv...

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Hoofdauteurs: Veronika Voronova, Victor Sokolov, Yannick Morias, Malin Jonsson Boezelman, Maria Wågberg, Marcus Henricsson, Karl Hansson, Alexey Goltsov, Kirill Peskov, Monika Sundqvist
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2022-11-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
BCAA
BCKA
BCKDK
BT2
cardiac hypertrophy
quantitative systems pharmacology
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2022.993422/full
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