Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum

Embryonic stem cells (ESCs) are characterized by the pluripotent capacity to generate all embryonic lineages. Here, we show that ESCs can occupy a spectrum of distinct transcriptional and epigenetic states in response to varied extrinsic conditions. This spectrum broadly corresponds to a development...

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Bibliografski detalji

Glavni autori:	Jamie A. Hackett, Toshihiro Kobayashi, Sabine Dietmann, M. Azim Surani
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2017-06-01
Serija:	Stem Cell Reports
Teme:	pluripotency chimeric transcripts DNA methylation PGC transposable element STAT3 embryonic stem cell imprints KLF4 heterogeneity
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2213671117302217
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