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Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method

N- Demethylsinomenine (NDSM), the in vivo demethylated metabolite of sinomenine, has exhibited antinociceptive efficacy against various pain models and may become a novel drug candidate for pain management. However, no reported analytical method for quantification of N- Demethylsinomenine in a biolo...

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Main Authors: Lulu Yu, Xunjia Qian, Yiheng Feng, Yujian Yin, Xiao-Dan Zhang, Qianqian Wei, Liyun Wang, Weiwei Rong, Jie-Jia Li, Jun-Xu Li, Qing Zhu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Chemistry
Subjects:
pharmacokinetics
bioavailability
N-demethylsinomenine
UPLC-MS/MS
rats
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1222560/full
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