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Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?

Host cells can recognize cytosolic double-stranded DNAs and endogenous second messengers as cyclic dinucleotides—including c-di-GMP, c-di-AMP, and cGAMP—of invading microbes via the critical and essential innate immune signaling adaptor molecule known as STING. This recognition activates the innate...

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Main Authors: Samira Elmanfi, Mustafa Yilmaz, Wilson W. S. Ong, Kofi S. Yeboah, Herman O. Sintim, Mervi Gürsoy, Eija Könönen, Ulvi K. Gürsoy
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-05-01
Series:Pathogens
Subjects:
periodontitis
bacterial recognition
nucleic acid
cyclic dinucleotides
STING
Online Access:https://www.mdpi.com/2076-0817/10/6/675
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