Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a protein therapeutic. However, use of LPL as a pro...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier
2018-12-01
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| Reeks: | Journal of Lipid Research |
| Onderwerpen: | |
| Online toegang: | http://www.sciencedirect.com/science/article/pii/S0022227520341705 |
| Tags: |
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