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Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotides. During ribosome biogenesis, modifications are added at va...

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Bibliografische Detailangaben
Hauptverfasser: Andrew D Bailey, Jason Talkish, Hongxu Ding, Haller Igel, Alejandra Duran, Shreya Mantripragada, Benedict Paten, Manuel Ares
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2022-04-01
Schriftenreihe:eLife
Schlagworte:
Online-Zugang:https://elifesciences.org/articles/76562
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