Non-canonical transcriptional regulation of the poor prognostic factor UGT2B17 in chronic lymphocytic leukemic and normal B cells

Abstract Background High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism. The key determinants driving expression...

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Hlavní autoři:	Michèle Rouleau, Lyne Villeneuve, Eric P. Allain, Jules McCabe-Leroux, Sophie Tremblay, Flora Nguyen Van Long, Ashwini Uchil, Charles Joly-Beauparlant, Arnaud Droit, Chantal Guillemette
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-04-01
Edice:	BMC Cancer
Témata:	Glycosyltransferase Leukemic B cells Alternative promoter STAT3 NF-κB Interferon regulation factors IRF
On-line přístup:	https://doi.org/10.1186/s12885-024-12143-7
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