The role of L-Arginine metabolism in the hallmarks of cancer as an emerging pathway to drug design

Cancer remains a leading cause of mortality worldwide and continues to challenge therapy due to its biological complexity and metabolic plasticity. Among the pathways supporting malignant progression, L-arginine metabolism has emerged as a key regulator of tumor cell fitness, integrating nutrient se...

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Autori principali:	Gael Garcia-Valdez, Angel Emiliano Vazquez-Galvan, Jose Luis Gonzalez-Llerena, Daniela Treviño-Almaguer, Daniela Liliana Gallegos-Ibarra, Daniela Guajardo-Gonzalez, Isaias Balderas-Renteria, Maria del Rayo Camacho-Corona, Bryan Alejandro Espinosa-Rodriguez
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Pharmacology
Soggetti:	cancer metabolism L-arginine auxotrophy L-arginine metabolism metabolic reprogramming tumor microenvironment
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1851940/full
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