Piper sarmentosum Promotes Endothelial Nitric Oxide Production by Reducing Asymmetric Dimethylarginine in Tumor Necrosis Factor-α-Induced Human Umbilical Vein Endothelial Cells

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS). ADMA is degraded by dimethylarginine dimethylaminohydrolase (DDAH). Elevated levels of ADMA lead to reduction in nitric oxide (NO) production, which is linked to endothelial dysfunction and ath...

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Hlavní autoři:	Uma Mahgesswary Sundar, Azizah Ugusman, Hui Kien Chua, Jalifah Latip, Amilia Aminuddin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-09-01
Edice:	Frontiers in Pharmacology
Témata:	Piper sarmentosum asymmetric dimethylarginine dimethylarginine dimethylaminohydrolase human umbilical vein endothelial cells tumor necrosis factor-α endothelial dysfunction
On-line přístup:	https://www.frontiersin.org/article/10.3389/fphar.2019.01033/full
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