Engineering the Rapid Adenovirus Production and Amplification (RAPA) Cell Line to Expedite the Generation of Recombinant Adenoviruses

Background/Aims: While recombinant adenoviruses are among the most widely-used gene delivery vectors and usually propagated in HEK-293 cells, generating recombinant adenoviruses remains time-consuming and labor-intense. We sought to develop a rapid adenovirus production and amplification (RAPA) line...

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Detalhes bibliográficos

Principais autores:	Qiang Wei, Jiaming Fan, Junyi Liao, Yulong Zou, Dongzhe Song, Jianxiang Liu, Jing Cui, Feng Liu, Chao Ma, Xue Hu, Li Li, Yichun Yu, Xiangyang Qu, Liqun Chen, Xinyi Yu, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Ruyi Zhang, Shujuan Yan, Xingye Wu, Yi Shu, Russell R. Reid, Michael J. Lee, Jennifer Moritis Wolf, Tong-Chuan He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cell Physiol Biochem Press GmbH & Co KG 2017-05-01
coleção:	Cellular Physiology and Biochemistry
Assuntos:	Adenoviral vectors Adenovirus production Packaging cell line Gene transfer Gene delivery
Acesso em linha:	http://www.karger.com/Article/FullText/475909
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