Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema

ABSTRACT Hereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein. Donidalorsen is an antisense oligonucleotide designed to selectively degrade prekallikrein messenger RNA and thereby reduce prekall...

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Bibliografische Detailangaben

Hauptverfasser:	John K. Diep, Miao Liu, Pratap Singh, Steve Dorow, Danny M. Cohn, Laura Bordone, Kenneth B. Newman, Xiang Gao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-02-01
Schriftenreihe:	CPT: Pharmacometrics & Systems Pharmacology
Schlagworte:	antisense oligonucleotide donidalorsen GalNAc hereditary angioedema model‐based drug development pharmacometrics
Online-Zugang:	https://doi.org/10.1002/psp4.70206
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