Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors, amplifying viral mRNA expression. The Tat inhibitor didehydro-cortistatin A (dCA) promotes a state of persistent latency, refractory...

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Autori principali:	Guillaume Mousseau, Rachna Aneja, Mark A. Clementz, Sonia Mediouni, Noemia S. Lima, Alexander Haregot, Cari F. Kessing, Joseph A. Jablonski, Suzie Thenin-Houssier, Nisha Nagarsheth, Lydie Trautmann, Susana T. Valente
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2019-08-01
Serie:	mBio
Soggetti:	HIV promoter HIV transcription Nef Tat inhibitor Vpr drug resistance
Accesso online:	https://journals.asm.org/doi/10.1128/mBio.01750-18
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