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Synthesis and Activity Evaluation of Novel Benzoxazepinone Derivatives as Potential Inhibitors of Glycogen Phosphorylase

Glycogen phosphorylase (GP) is a key enzyme of glycogen catabolism, so it is significant to discover a new GP inhibitor. A series of benzoxazepinone derivatives were identified as glycogen phosphorylase (GP) inhibitors with potent activity. These compounds exhibited strong inhibitory effects. Among...

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Principais autores: Dezhi Peng, Youde Wang, Zhiwei Yan, Shuai Li, Yachun Guo, Tienan Wang, Liying Zhang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-10-01
Serier:Molecules
Fag:
benzoxazepinone derivatives
glycogen phosphorylase inhibitors
biological activity
molecular docking
glycogen degradation
Online adgang:https://www.mdpi.com/1420-3049/30/21/4249
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