Safety and immunogenicity in humans of enterotoxigenic Escherichia coli double mutant heat-labile toxin administered intradermally

Abstract Enterotoxigenic Escherichia coli (ETEC) diarrhea is associated with a high burden of disease globally, for which no licensed vaccine is available. A Phase 1, double-blind, dose-escalation (0.1-2.0 µg) study was conducted to evaluate the safety and immunogenicity of double mutant heat-labile...

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Principais autores:	Marcela F. Pasetti, Patricia L. Milletich, Jessica A. White, Jessica Butts, Rebecca C. Brady, Michelle D. Dickey, Cassandra Ballou, Nicole Maier, Marcelo B. Sztein, Shahida Baqar, A. Louis Bourgeois, David I. Bernstein
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-02-01
Series:	npj Vaccines
Acceso en liña:	https://doi.org/10.1038/s41541-025-01071-7
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