Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation

Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 induction in human CD4+ T cells. Thus, lack of autocr...

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Principais autores:	Simon Freeley, John Cardone, Sira C. Günther, Erin E. West, Thomas Reinheckel, Colin Watts, Claudia Kemper, Martin V. Kolev
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-10-01
coleção:	Frontiers in Immunology
Assuntos:	complement CD46 T cell cathepsin L AEP legumain
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02449/full
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