Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation

In this report, we describe the synthesis and characterization of 1,3-bis(hexyloxy)propan-2-yl nitrate (NDHP), a novel organic mono nitrate. Using purified xanthine oxidoreductase (XOR), chemiluminescence and electron paramagnetic resonance (EPR) spectroscopy, we found that XOR catalyzes nitric oxid...

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Bibliografische Detailangaben

Hauptverfasser:	Zhengbing Zhuge, Luciano L. Paulo, Arghavan Jahandideh, Maria C.R. Brandão, Petrônio F. Athayde-Filho, Jon O. Lundberg, Valdir A. Braga, Mattias Carlström, Marcelo F. Montenegro
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2017-10-01
Schriftenreihe:	Redox Biology
Schlagworte:	Nitric oxide Organic nitrates Xanthine oxidoreductase Tolerance Nitrite Nitrate
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231717302057
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