Defining differential genetic signatures in CXCR4- and the CCR5-utilizing HIV-1 co-linear sequences.

The adaptation of human immunodeficiency virus type-1 (HIV-1) to an array of physiologic niches is advantaged by the plasticity of the viral genome, encoded proteins, and promoter. CXCR4-utilizing (X4) viruses preferentially, but not universally, infect CD4+ T cells, generating high levels of virus...

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Principais autores:	Benjamas Aiamkitsumrit, Will Dampier, Julio Martin-Garcia, Michael R Nonnemacher, Vanessa Pirrone, Tatyana Ivanova, Wen Zhong, Evelyn Kilareski, Hazeez Aldigun, Brian Frantz, Matthew Rimbey, Adam Wojno, Shendra Passic, Jean W Williams, Sonia Shah, Brandon Blakey, Nirzari Parikh, Jeffrey M Jacobson, Brian Moldover, Brian Wigdahl
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Acceso en liña:	http://europepmc.org/articles/PMC4180074?pdf=render
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