Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption

Tamoxifen (TAM) is a widely used estrogen receptor modulator for breast cancer treatment. However, TAM exhibits significant hepatotoxicity in the clinic, affecting nearly 50% of patients and thereby limiting its clinical utility. The specific mechanisms underlying TAM-induced liver injury remain poo...

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Váldodahkkit:	Yuchun Chen, Haiyan Du, Wenxin Zhou, Meirong Qin, Meifang Li, Yibao Jin, Yaning Xu, Chong Ma, Jiaxuan Xia, Yongshi Mo, Ning Chen, Houshuang Huang, Hao Li, Zhiyong Xie, Ping Wang, Yanjun Hong
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Taylor & Francis Group 2026-12-01
Ráidu:	Gut Microbes
Fáttát:	Tamoxifen-induced liver injury gut microbiota hyodeoxycholic acid Farnesoid X receptor signaling
Liŋkkat:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2610077
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