Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis

Abstract Background Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment is characterized by high lactate levels, acting not only as an e...

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मुख्य लेखकों:	Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	BMC 2025-01-01
श्रृंखला:	Journal of Translational Medicine
विषय:	Lactate Myelofibrosis Tumor microenvironment Monocarboxylate transporters
ऑनलाइन पहुंच:	https://doi.org/10.1186/s12967-025-06083-4
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