A growth-coupled progesterone-responsive biosensor for high-throughput microfluidic screening in Saccharomyces cerevisiae

Poor aqueous solubility of steroid precursors, such as pregnenolone and progesterone, limits microbial biotransformation and high-throughput strain screening, representing a bottleneck for strain improvement and potential industrial applications.To address this, we developed a growth-coupled progest...

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Detalhes bibliográficos

Principais autores:	Yucheng Hu, Jinde Chen, Shaofang Tian, Yang Zhang, Zhiqian Zhang, Ao Jiang, Yi-Rui Wu, Baoshun Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2026-06-01
coleção:	Synthetic and Systems Biotechnology
Assuntos:	Progesterone-responsive biosensor Growth-coupled selection ARTP mutagenesis Fluorescence-activated droplet sorting Saccharomyces cerevisiae Steroid biotransformation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405805X25002078
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