Synthesis, Characterization, and Antifungal Evaluation of Thiolactomycin Derivatives

5-Substituted benzylidene 3-acylthiotetronic acids are antifungal. A series of 3-acylthiotetronic acid derivatives with varying substitutions at the 5-position were designed, synthesized, and characterized, based on the binding pose of 3-acyl thiolactone with the protein C171Q KasA. Fungicidal activ...

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Hauptverfasser:	Pei Lv, Yiliang Chen, Dawei Wang, Xiangwei Wu, Qing X. Li, Rimao Hua
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-05-01
Schriftenreihe:	Engineering
Schlagworte:	3-Acylthiotetronic acid Fungicide Quantitative structure–activity relationship Antifungal activity
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2095809918315066
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