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DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway

Background Hepatic fibrosis is a common response to chronic liver injury. Recently, the role of DZNep (a histone methyltransferase EZH2 inhibitor) in repressing pulmonary and renal fibrosis was verified. However, the potential effect of DZNep on hepatic fibrosis has not been elucidated. Methods The...

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Détails bibliographiques
Auteurs principaux: Rongrong Ding, Jianming Zheng, Ning Li, Qi Cheng, Mengqi Zhu, Yanbing Wang, Xinlan Zhou, Zhanqing Zhang, Guangfeng Shi
Format: Artigo
Langue:Inglês
Publié: PeerJ Inc. 2021-05-01
Collection:PeerJ
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Accès en ligne:https://peerj.com/articles/11374.pdf
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