TNF-α blockade with adalimumab restores bone metabolism in rheumatoid arthritis by regulating cytokines and inflammatory cell infiltration

ObjectiveTo investigate the mechanisms underlying the bone-sparing effects of the anti-TNF antibody adalimumab in rheumatoid arthritis (RA) by examining synovial tissue and its direct effect on osteoblasts and osteoclasts.MethodsPaired synovial biopsies from 12 patients with RA were obtained before...

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Autors principals:	Akilan Krishnamurthy, Shankar Revu, Petra Neregård, Aase Hensvold, Erik af Klint, Dimitrios Makrygiannakis, Anca I. Catrina, Ioannis Parodis
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	anti-TNF-α biologics bone erosion osteoblasts osteoclasts rheumatoid arthritis
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1866519/full
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