MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia

IntroductionHereditary α-tryptasemia (HαT), defined by increased TPSAB1 copy number and elevated basal serum tryptase, is associated with mast cell (MC)–mediated symptoms. However, its role in gastrointestinal disease remains unclear. Because intestinal MCs express the non–IgE-dependent activation r...

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Bibliografische Detailangaben

Hauptverfasser:	Michelle Galeas-Pena, Jonathan J. Lyons, Dhana Llivichuzhca-Loja, Steve Everman, Ghina Yaghi, Katelyn White, Sangita Sutradhar, Tanya O. Robinson, Anna H. Owings, Neha S. Dhaliwal, Alexander Carlye, Liza Konnikova, Hydar Ali, Sarah C. Glover
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-01-01
Schriftenreihe:	Frontiers in Allergy
Schlagworte:	gastrointestinal tract hereditary alpha-tryptasemia inflammatory bowel disease mass cytometry mast cells MRGPRX2
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/falgy.2025.1726096/full
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