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Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure.

Viral reservoirs that persist in HIV-1 infected individuals on antiretroviral therapy (ART) are the major obstacle to viral eradication. The identification and definition of viral reservoirs in patients on ART is needed in order to understand viral persistence and achieve the goal of viral eradicati...

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Autori principali: Mark Sharkey, Dunja Z Babic, Thomas Greenough, Roy Gulick, Daniel R Kuritzkes, Mario Stevenson
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2011-02-01
Serie:PLoS Pathogens
Accesso online:http://europepmc.org/articles/PMC3044693?pdf=render
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