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Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity

Gliotoxin (GT) is a mycotoxin produced by some species of ascomycete fungi including the opportunistic human pathogen Aspergillus fumigatus. In order to produce GT the host organism needs to have evolved a self-protection mechanism. GT contains a redox-cycling disulfide bridge that is important in m...

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Principais autores: Elizabeth B. Smith, Stephen K. Dolan, David A. Fitzpatrick, Sean Doyle, Gary W. Jones
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2016-02-01
Serier:Microbial Cell
Fag:
gliotoxin
Aspergillus fumigatus
Saccharomyces cerevisiae
oxidoreductase GliT
thio-methyltransferase GtmA
Online adgang:http://microbialcell.com/researcharticles/towards-understanding-the-gliotoxin-detoxification-mechanism-in-vivo-thiomethylation-protects-yeast-from-gliotoxin-cytotoxicity/
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