Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells

Abstract The function of a protein is determined by its structure, which may change dynamically in response to post-translational modifications, interaction with other molecules, or environmental factors like temperature. Limited proteolysis-coupled mass spectrometry (LiP-MS) captures such structura...

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Detalhes bibliográficos

Principais autores:	Franziska Elsässer, Roberta Florea, Felix Räsch, Mostafa Zedan, Nesli-Ece Sen, Tim Pflästerer, Tatjana Kleele, Robbie Loewith, Karsten Weis, Natalie de Souza, Paola Picotti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-01-01
coleção:	Molecular Systems Biology
Assuntos:	LiP-MS Structural Proteomics Stress Granules Nuclear Speckles Biomolecular Condensation
Acesso em linha:	https://doi.org/10.1038/s44320-025-00182-6
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