Case Report: Medullary carcinoma of the pancreas with MLH1 promoter hypermethylation, induced deficient mismatch repair, successfully treated with an immune checkpoint inhibitor

We report the case of a 75-year-old woman with a pancreatic body mass. Pathological findings from endoscopic ultrasonography-guided fine-needle aspiration revealed medullary carcinoma of the pancreas (MCP). Deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H) were identified...

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Autors principals:	Koushiro Ohtsubo, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Akihiro Nishiyama, Kaname Yamashita, Seiji Yano, Fumihito Toshima, Dai Inoue, Toshifumi Gabata, Hiroko Ikeda, Atsushi Watanabe, Kenji Notohara, Takao Fujisawa, Yoshiaki Nakamura, Takayuki Yoshino, Kunio Miyake, Kazuhiro Miwa, Shinji Takeuchi
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-03-01
Col·lecció:	Frontiers in Oncology
Matèries:	medullary carcinoma of the pancreas deficient mismatch repair microsatellite instability MLH1 hypermethylation immune checkpoint inhibitor pembrolizumab
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1551038/full
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