Pterostilbene attenuates osteoarthritis progression through p53-dependent autophagy activation: evidence from network analysis and experimental validation

BackgroundOsteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage destruction and functional impairment. Dysregulated autophagy plays a pivotal role in chondrocyte apoptosis and extracellular matrix (ECM) degradation. Pterostilbene (PT), a natural polyphenolic metabo...

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Bibliographic Details

Main Authors:	Jiangping Wu, Chunpan Zhang, Yuanyuan Qin, Lixuan Zhu, Lingyan Liu, Fei Xu
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-01-01
Series:	Frontiers in Pharmacology
Subjects:	autophagy chondroprotection network analysis osteoarthritis p53/AMPK/mTOR axis pterostilbene
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1686555/full
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