Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery
Hedgehog (Hh) signaling plays pivotal roles in embryonic development. In adults, Hh signaling is mostly turned off but its abnormal activation is involved in many types of cancer. Hh signaling is initiated by the Hh ligand, generated from the Hh precursor by a specialized autocatalytic process calle...
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| Huvudupphov: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
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Frontiers Media S.A.
2022-05-01
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| Serie: | Frontiers in Molecular Biosciences |
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| Länkar: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.900560/full |
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