Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma

Abstract Background Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kinase inhibitors (TKIs) in lung cancer have not yet been reported in G...

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Detalhes bibliográficos

Principais autores:	Lea Loriguet, Mony Chenda Morisse, Julie Dremaux, Louison Collet, Christophe Attencourt, Alexandre Coutte, Mathieu Boone, Henri Sevestre, Antoine Galmiche, Brigitte Gubler, Bruno Chauffert, Stephanie Trudel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-10-01
coleção:	BMC Cancer
Assuntos:	Glioblastoma EGFR Activating kinase mutation Tyrosine kinase inhibitors Afatinib Next-generation sequencing
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-018-4873-9
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