The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population.
<h4>Background</h4>Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is the most common cause of monogenic forms of obesity. However, these mutations have often been identified in small-scale, case-focused studies. Here, we assess the penetrance of previously reported MC4R muta...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2020-07-01
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| Serija: | PLoS Medicine |
| Online dostop: | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003196&type=printable |
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