Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells

Siglec-7 (sialic acid–binding immunoglobulin-like lectin 7) is an immune checkpoint-like glycan recognition protein on natural killer (NK) cells. Cancer cells often upregulate Siglec ligands to subvert immunosurveillance, but the molecular basis of Siglec ligands has been elusive. In this study, we...

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Autori principali:	Lan-Yi Chang, Suh-Yuen Liang, Shao-Chia Lu, Huan Chuan Tseng, Ho-Yang Tsai, Chin-Ju Tang, Marcelia Sugata, Yi-Ju Chen, Yu-Ju Chen, Shang-Ju Wu, Kuo-I Lin, Kay-Hooi Khoo, Takashi Angata
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-05-01
Serie:	Frontiers in Immunology
Soggetti:	chronic lymphocytic leukemia natural killer cells Siglec-7 sialomucin ST6GalNAc-IV Core 2 GlcNAc transferase
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.840388/full
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