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Identification of immune-related diagnostic genes and immune cell infiltration in aseptic loosening of prostheses after total hip arthroplasty by integrated bioinformatics analysis and experimental confirmation

BackgroundAseptic loosening (AL) of hip prostheses is one of the main reasons for revision total hip arthroplasty (rTHA). However, the transcriptomic characteristics of AL are scarcely understood. This study aimed to discover candidate biomarkers for the diagnosis of AL.Patients and methodsThe inter...

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Principais autores: Yunke Liu, Xiaming Liang, Shuo Qiang, Yonghui Dong, Xin Zhao, Lichao Ma, Zhihua Yan, Songkai Yue, Yifan Huang, Jia Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-08-01
coleção:Frontiers in Genetics
Assuntos:
aseptic loosening
total hip arthroplasty
macrophages
bioinformatics
immune infiltration
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2025.1597219/full
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