Gut microbiota alterations may increase the risk of prescription opioid use, but not vice versa: A two-sample bi-directional Mendelian randomization study

IntroductionGut microbiota alterations are strongly associated with prescription opioid use (POU) and multisite chronic pain (MCP). However, whether or not these associations are causal remains unknown. Therefore, we aim to explore the causal relationships between them comprehensively.MethodsA two-s...

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Detalhes bibliográficos

Principais autores:	Liling Lin, Jianwei Lin, Junxiong Qiu, Feng Wei, Xiaohui Bai, Weiying Ma, Jingxian Zeng, Daowei Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-11-01
coleção:	Frontiers in Microbiology
Assuntos:	causality prescription opioid use multisite chronic pain gut microbiota metabolites Mendelian randomization
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.994170/full
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