Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan

Abstract Background Low-grade systemic inflammation may be a key player in the immune activation that has been reported for mental health deterioration. We hypothesised that elevated serum levels of inflammatory cytokines increase neuroinflammation and exacerbate depressive symptoms. Methods The par...

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Κύριοι συγγραφείς:	Hirohito Tsuboi, Hiroyuki Sakakibara, Yuuki Minamida-Urata, Hiromasa Tsujiguchi, Akinori Hara, Keita Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Takayuki Kannon, Jiaye Zhao, Yukari Shimizu, Aki Shibata, Aya Ogawa, Fumihiko Suzuki, Yasuhiro Kambayashi, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2024-10-01
Σειρά:	BioPsychoSocial Medicine
Θέματα:	Low-grade inflammation Depressive symptoms Inflammatory cytokines Interleukin (IL)-17 Tumour necrosis factor (TNF)α Community-based cohort study
Διαθέσιμο Online:	https://doi.org/10.1186/s13030-024-00317-5
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