Suppression of the PI3K/AKT/mTOR signaling pathway by PDYN alleviates sepsis-associated encephalopathy in mice

Background: Microglial pyroptosis-mediated neuroinflammation is a key pathogenic mechanism in Sepsis-Associated Encephalopathy (SAE). However, the role of prodynorphin (PDYN) in SAE and the relationship between PDYN and microglial pyroptosis remain unknown. Methods: Mice were subjected to cecal liga...

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Bibliographic Details

Main Authors:	Ao Li, Shujuan Qu, Shengfeng Wang, Qiong Guo, Sinian Tan, Mao Peng, Lin Liu
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-02-01
Series:	Brain Research Bulletin
Subjects:	Prodynorphin Microglia pyroptosis PI3K/AKT/mTOR signaling Sepsis-associated encephalopathy
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923026000201
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