Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in <italic toggle="yes">Saccharomyces cerevisiae</italic>

ABSTRACT Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is tightly regulated by 25 known enzymes along the ERG production pathway. The effects of changes in expression of each ERG biosynthesis enzyme in Saccharomyces cerevisiae were analyzed by the use of...

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Auteurs principaux:	Somanon Bhattacharya, Brooke D. Esquivel, Theodore C. White
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2018-09-01
Collection:	mBio
Sujets:	Saccharomyces cerevisiae antifungal drug resistance ergosterol biosynthesis ergosterol gene overexpression ergosterol regulation stress agents
Accès en ligne:	https://journals.asm.org/doi/10.1128/mBio.01291-18
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