Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma

Abstract Tumor cell plasticity drives metastasis and therapy resistance, yet its regulation by oncoprotein dosage dynamics remains poorly understood. In Ewing sarcoma (EwS), variations in EWS::FLI1 (EF) fusion oncoprotein activity have been associated with epithelial-mesenchymal plasticity (EMP). Us...

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Detalhes bibliográficos

Principais autores:	Veveeyan Suresh, Christoph Hafemeister, Andri Konstantinou, Sarah Grissenberger, Caterina Sturtzel, Martha M Zylka, Florencia Cidre-Aranaz, Andrea Wenninger-Weinzierl, Karla Queiroz, Dorota Kurek, Martin Distel, Anna Obenauf, Thomas G P Grünewald, Florian Halbritter, Heinrich Kovar, Valerie Fock
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-01-01
coleção:	EMBO Molecular Medicine
Assuntos:	Epithelial Mesenchymal Plasticity Ewing Sarcoma EWS::FLI1 Metastasis Oncogene Fluctuation
Acesso em linha:	https://doi.org/10.1038/s44321-025-00364-7
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