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Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis

Abstract Background Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in the pathogenesis of OA. Recent advancements...

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Principais autores: Yong Fu, Jiahui Hou, Qinmeng Yang, Yanpeng Lin, Nie Rui, Jun Wang, Hangtian Wu, Bin Yu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Journal of Nanobiotechnology
Fag:
WGCNA
SIK1
AICAR
Macrophage metabolism
Nanoliposome composite hydrogel
Osteoarthritis
Online adgang:https://doi.org/10.1186/s12951-025-03543-3
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